-
"Beauty
and the Beast: Molecular Prospecting for Novel Drugs from the Sea".
by Bruce Livett's; Address to The Royal Society of Victoria, Thursday
13 March 1997.
(Link problems: http://www.sciencevictoria.org.au/ord397.htm)
(http://grimwade.biochem.unimelb.edu.au/cone/resource.html)
- Snail
toxin could ease chronic pain:Nature - Science Update: New painkiller
may be 10,000 times stronger than morphine. 19 July 2002 by INGRID HOLMES
-
Clams
and Cancer: In the early 1980s, MBL researchers Joan Ruderman
and Tim hunt discovered a previously unknown protein in fertilized
clam eggs. Interestingly, the protein accumulated and then disappeared
as cells prepared to divide and then divided. The protein, dubbed
cyclin, turned out to be a regulator of cell division…”
- Cancer:
DTP - Natural
Product Extract Cancer Screening Data: Cancer Cell Line Screening
Data for Extracts in the Family Pinnidae
- Cognetix,
Inc..."is developing therapeutics based on research in marine
natural products. The Company's most advanced product research and development
efforts are based on 'conopeptides,' peptides derived from the venom
of Conus species of predatory sea snails...Cognetix believes that the
ultra-high specificity of the conopeptides should enable the development
of novel, highly efficacious drugs with minimal side effects for treatment
of central and peripheral nervous system disorders and cardiovascular
disorders...."
- Elan
Corporation, plc. In January 2000, Cognetix and Elan agreed
to establish a joint venture (called Erinetix™) to develop Cognetix'
contulakin-G (CGX-1160) as a treatment for post-operative pain.
-
Medtronic,
Inc. In February 1999, the Company entered into collaboration
and investment agreements with Medtronic to support the development
of a conantokin-based drug for delivery in a refillable Medtronic
SynchroMed® implantable pump to treat severe epilepsy.
-
JBC online:--
Loughnan et al. 273 (25): 15667: From the Centre for Drug Design
and Development and Dept of Physiology and Pharmacology,
The University of Queensland, St. Lucia Queensland 4067, Australia
and ¶ The Department of Biochemistry and Molecular
Biology, The University of Melbourne, Parkville Victoria 3052, Australia
Cone snail venoms contain complex mixtures of peptides (conotoxins
or conopeptides) that bind with high affinity and specificity to a
diversity of mammalian ...
-
Molecular Neurobiology
- Dr. Olivera:
... ca. 50,000 different pharmacologically-active peptides in the
venoms of living cone snails; several of these are being developed
for direct therapeutic use. ...
-
Rockpool Medicine:
Thursday, 13 April 2000; “This is the story of Kirsten
Benkendorff who recently discovered a new kind of antibiotic in the
eggs of a common sea snail. As part of her Ph.D. thesis, she searched
the shores around Wollongong, collecting and testing the eggs of more
than 40 marine molluscs that live in rock pools. The common dog whelk's
eggs yielded a chemical as powerful as penicillin…”
-
Snail
neurobiology: by Chris Elliott, Lecturer
in Biology
-
Snails,
Science and Sussex: "The Sussex Centre for Neuroscience is
an Interdisciplinerary Research Centre based in the School of Biological
Sciences(here's a picture of Biols building in the snow) at the University
of Sussex. Most of the work is based on the model systems of the pond
snail, Lymnaea stagnalis and other invertebrates like the locust,
cockroach and Drosophila."
-
Squid and Neurological
Disorders: “Endowed with a stunningly large nerve cell (or Axon),
the Woods Hole squid has contributed so much to the study of nerve
structure and function that one biologist has suggested the Nobel
Prize...
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